RADIOPROTECTION: MECHANISMS AND RADIOPROTECTIVE AGENTS INCLUDING HONEYBEE VENOM

Radioprotective agents pdf

Hematological Alterations in Albino Rats after Administration of Honeybee Venom

Bee venom is a complex mixture of proteins (enzymes and peptides) with unique pharmacological activities. The main enzymes in bee venom are hyaluronidase and phopholiphase A2. Melittin in high concentrations also has caused hemolysis of red blood cells. This study was conducted to evaluate effects of honeybee venom on hematological characteristics of albino rats. Rats were divided in 3 groups v...

Radioprotection of sensitive rat tissues by oligoelements Se, Zn, Mn plus Lachesis muta venom.

In this study we first evaluated the general radioprotective efficacy of Se, Zn and Mn (4 µg/ml each) plus Lachesis muta venom (4 ng/ml) combination (O-LM) by determining survival on rats irradiated with lethal doses of gamma-rays. The aim of the second part of the study was to investigate the O-LM ability to prevent ionizing radiation-induced damage on small intestine, bone marrow and submandi...

Radioprotection and Molecular Therapy

The dose limiting toxicities of Ionizing Radiation (IR) in radiosensitive normal tissues, such as bone marrow, intestine, and skin, precludes the delivery of curative or effective palliative doses of radiation in many cases. Despite of the intense research effort in the past to find new effective and well-tolerated radioprotectors, only one drug has been approved by FDA for this indication. One...

Natural Radioprotective Agents against Ionizing Radiation – An Overview

Ionizing radiations are one of the predominant exogenous factors that have deleterious consequences to human life The biological effects of the radiation cause damages to DNAs, lipids and proteins. Exposure to high amounts of ionizing radiation causes damages to the hematopoietic, gastrointestinal or central nervous systems, depending on radiation dose. Hence, there is an urgent need to prevent...